Legislature(2011 - 2012)CAPITOL 106

02/17/2011 03:00 PM House HEALTH & SOCIAL SERVICES


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03:06:46 PM Start
03:07:16 PM Presentation: Vitamin D
04:43:19 PM Adjourn
* first hearing in first committee of referral
+ teleconferenced
= bill was previously heard/scheduled
+ Presentation: Vitamin D TELECONFERENCED
                    ALASKA STATE LEGISLATURE                                                                                  
      HOUSE HEALTH AND SOCIAL SERVICES STANDING COMMITTEE                                                                     
                       February 17, 2011                                                                                        
                           3:06 p.m.                                                                                            
                                                                                                                                
MEMBERS PRESENT                                                                                                               
                                                                                                                                
Representative Wes Keller, Chair                                                                                                
Representative Alan Dick, Vice Chair                                                                                            
Representative Paul Seaton                                                                                                      
Representative Bob Miller (via teleconference)                                                                                  
Representative Charisse Millett (via teleconference)                                                                            
                                                                                                                                
MEMBERS ABSENT                                                                                                                
                                                                                                                                
Representative Bob Herron                                                                                                       
Representative Sharon Cissna                                                                                                    
                                                                                                                                
OTHER LEGISLATORS PRESENT                                                                                                     
                                                                                                                              
Senator Cathy Giessel                                                                                                           
                                                                                                                                
COMMITTEE CALENDAR                                                                                                            
                                                                                                                                
PRESENTATION:  VITAMIN D                                                                                                        
                                                                                                                                
     - HEARD                                                                                                                    
                                                                                                                                
PREVIOUS COMMITTEE ACTION                                                                                                     
                                                                                                                                
No previous action to record                                                                                                    
                                                                                                                                
WITNESS REGISTER                                                                                                              
                                                                                                                                
DR. ROBERT HEANEY                                                                                                               
Creighton University Osteoporosis Research Center                                                                               
Creighton University School of Medicine                                                                                         
Creighton University                                                                                                            
Omaha, Nebraska                                                                                                                 
POSITION STATEMENT:  Presented a PowerPoint, "Vitamin D: Miracle                                                              
Nutrient or Snake Oil The Challenge for Alaska" and answered                                                                    
questions during the presentation.                                                                                              
                                                                                                                                
CAROLE A BAGGERLY, Director                                                                                                     
GrassrootsHealth                                                                                                                
Encinitas, California                                                                                                           
POSITION STATEMENT:  Presented a  PowerPoint, "Vitamin D Prevents                                                             
What's Next?" and answered questions during the presentation.                                                                   
                                                                                                                                
                                                                                                                                
ACTION NARRATIVE                                                                                                              
                                                                                                                                
3:06:46 PM                                                                                                                    
                                                                                                                                
CHAIR  WES KELLER  called the  House Health  and Social  Services                                                             
Standing   Committee    meeting   to    order   at    3:06   p.m.                                                               
Representatives Keller,  Seaton, Miller (via  teleconference) and                                                               
Millett (via teleconference)  were present at the  call to order.                                                               
Representative  Dick  arrived as  the  meeting  was in  progress.                                                               
Also in attendance was Senator Geissel.                                                                                         
                                                                                                                                
^PRESENTATION:  Vitamin D                                                                                                       
                    PRESENTATION:  Vitamin D                                                                                
                                                                                                                              
3:07:16 PM                                                                                                                    
                                                                                                                                
CHAIR KELLER announced  that the only order of  business would be                                                               
a presentation  on Vitamin D.   He  expressed his pleasure  for a                                                               
presentation on a preventative resource.                                                                                        
                                                                                                                                
3:08:58 PM                                                                                                                    
                                                                                                                                
REPRESENTATIVE   SEATON   explained   that,  after   watching   a                                                               
University of California television special  on Vitamin D, he had                                                               
urged the  scheduling for  this hearing.   He offered  his belief                                                               
that Vitamin D could reduce  health and cost impacts on Alaskans,                                                               
while improving their lives.                                                                                                    
                                                                                                                                
3:11:17 PM                                                                                                                    
                                                                                                                                
DR.  ROBERT HEANEY,  Creighton  University Osteoporosis  Research                                                               
Center,  Creighton  University   School  of  Medicine,  Creighton                                                               
University,  said that  his investigations  had convinced  him of                                                               
the need  to convey more  information and facts about  Vitamin D,                                                               
and to offer  some options for its use.   He referred to proposed                                                               
House  Concurrent   Resolution  5,  "A  resolution   relating  to                                                               
prevention of disease and to  Vitamin D."  Directing attention to                                                               
his PowerPoint,  "Vitamin D: Miracle  Nutrient or Snake  Oil," he                                                               
addressed slide  2, "Out  of Africa,"  and explained  that humans                                                               
had  evolved  in equatorial  East  Africa,  were originally  dark                                                               
skinned,  and,  as they  wore  no  clothes,  would have  made  an                                                               
abundance of  vitamin D,  year-round.   He moved  on to  slide 3,                                                               
"Cutaneous Vitamin  D Synthesis," and stated  that ultra-violet B                                                               
rays   from   the   sun   acted    on   a   skin   compound,   7-                                                               
dehydrocholesterol,  which was  converted to  pre-vitamin D,  and                                                               
then  spontaneously into  vitamin  D, which  was slowly  absorbed                                                               
into the bloodstream.                                                                                                           
                                                                                                                                
DR. HEANEY  explained slide  4 and  slide 5,  "Vit D  - Canonical                                                               
Scheme," stating that  the Vitamin D was stored in  the liver, as                                                               
25(OH)D3, which  was the  functional indicator  of the  vitamin D                                                               
status.                                                                                                                         
                                                                                                                                
3:15:08 PM                                                                                                                    
                                                                                                                                
DR. HEANEY  explained that slide  6 , "Healthy Range  - 25(OH)D,"                                                               
reflected  the  two  different units  for  measuring  vitamin  D,                                                               
nanograms  per  milliliter  [ng/mL],   and  nanomoles  per  liter                                                               
[nmol/L].  He  announced that the low end for  a healthy range of                                                               
vitamin D was 40 ng/ml or 100 nmol/L.                                                                                           
                                                                                                                                
3:16:01 PM                                                                                                                    
                                                                                                                                
DR. HEANEY, referring  to slide 7, "Vitamin D  & Primate Progress                                                               
(?)" talked about the timeline  chart which reflected the vitamin                                                               
D  levels for  Old-World Primates  up to  the 43  degree Northern                                                               
Latitude people  who were taking  4000 individual units  (IU) per                                                               
day.                                                                                                                            
                                                                                                                                
3:17:20 PM                                                                                                                    
                                                                                                                                
DR.  HEANEY,  commenting  on  slide  8,  "The  Primitive  Level,"                                                               
compared the dress of the Bantu  and the Maasai tribes in Africa,                                                               
and concluded that  there needed to be skin  exposure for vitamin                                                               
D absorption from the sun.                                                                                                      
                                                                                                                                
3:18:20 PM                                                                                                                    
                                                                                                                                
DR. HEANEY  considered slide 9,  "25(OH)D in the  Tropics," which                                                               
detailed a  study of  42 older Mayan  men in  tropical Guatemala,                                                               
listed their mean vitamin D as  25 ng/mL, and also concluded that                                                               
there needed to be skin exposure for vitamin D absorption.                                                                      
                                                                                                                                
3:19:07 PM                                                                                                                    
                                                                                                                                
DR.  HEANEY continued  on to  slide  10, "Out  of Africa,"  which                                                               
depicted   the  migration   out   of  Africa   and  the   reduced                                                               
availability of  Vitamin D,  as clothing  covered even  more skin                                                               
surface,  and   latitude  and  cloud  cover   reduced  the  solar                                                               
irradiance.  From  slide  11,  "Rickets  &  Group  Survival,"  he                                                               
detailed  that darker  skin pigmentation  acted  as a  sunscreen,                                                               
which reduced the vitamin D availability  to the skin, and led to                                                               
rickets  which distorted  the  pelvis  and prevented  childbirth.                                                               
Consequently,   only  paler   skinned  migrants   were  able   to                                                               
reproduce, or the race would have died out.                                                                                     
                                                                                                                                
3:20:14 PM                                                                                                                    
                                                                                                                                
DR. HEANEY  described that slide  12, "Number of months  in which                                                               
solar UV-B  can induce cutaneous vitamin  D synthesis," reflected                                                               
Vitamin D synthesis  in the temperate latitudes  and the tropics.                                                               
He  declared that  in Southeast  Alaska there  was not  vitamin D                                                               
synthesis for more  than six months of the year,  and in northern                                                               
Alaska, as the sun  was so low on the horizon,  there was not any                                                               
cutaneous vitamin  D synthesis.   He  supported the  logic behind                                                               
proposed HCR  5, as  most Alaskans need  a year  round supplement                                                               
for Vitamin  D.  He pointed  out that skin color  became steadily                                                               
paler the  further from  the equator, as  this was  necessary for                                                               
survival.                                                                                                                       
                                                                                                                                
3:22:17 PM                                                                                                                    
                                                                                                                                
DR. HEANEY  summarized slide  13, slide 14,  slide 15,  slide 16,                                                               
and  slide 17,  "Vitamin  D  - Sources,"  sharing  that the  sun,                                                               
natural foods,  and supplements  were the  sources of  vitamin D.                                                               
He opined that the year round  average of sun vitamin D was about                                                               
500 IU/day in Alaska, about 150  IU/day from food, and possibly a                                                               
few hundred  from supplements.   He stated  that the  body needed                                                               
4000 IU/day, so it was  necessary for supplementation.  Referring                                                               
to slide  18 and  slide 19,  "Latitude vs.  Sun," he  explained a                                                               
study with participants in Hawaii  and in Anchorage that measured                                                               
the  skin  pigmentation,  the blood  vitamin  D,  individual  sun                                                               
exposure and  diet.   He shared that  both groups  measured about                                                               
70nmol/L, which was  below the low end of the  healthy range, 100                                                               
nmol/L.   The following year,  another study was  conducted which                                                               
included beach  people in Hawaii,  whose vitamin D was  above 120                                                               
nmol/L.   He stated the necessity  of not only living  in a sunny                                                               
area, but getting out into the sun.                                                                                             
                                                                                                                                
3:24:26 PM                                                                                                                    
                                                                                                                                
DR. HEANEY  pondered slide  20, "What is  the evidence  that this                                                               
low vitamin  D status matters?"   He directed attention  to slide                                                               
21, "What  are the  Consequences?" and listed  a variety  of bone                                                               
diseases,  high   blood  pressure,  increased  risk   of  cardiac                                                               
disease,  diabetes, complications  in pregnancy,  and periodontal                                                               
disease as a partial list.                                                                                                      
                                                                                                                                
3:25:11 PM                                                                                                                    
                                                                                                                                
DR. HEANEY indicated slide 22 and  slide 23, "Small Changes - Big                                                               
Effects," which reflected a distribution  curve of systolic blood                                                               
pressure  in  a  normal  population.    He  pointed  out  that  a                                                               
reduction  of 4  mm of  blood pressure  lowered the  hypertensive                                                               
group by almost 50 percent.                                                                                                     
                                                                                                                                
3:27:26 PM                                                                                                                    
                                                                                                                                
DR.  HEANEY introduced  slide 24,  "Classical Vit  D Deficiency,"                                                               
noting  that rickets  in  children was  a  manifestation of  poor                                                               
absorption of calcium,  and indicated a vitamin D  level below 10                                                               
ng/ml.   He said that childhood  rickets could be prevented  by a                                                               
daily dose of  200-400 IU of vitamin D, although  this dose would                                                               
not restore full calcium absorptive function.                                                                                   
                                                                                                                                
3:28:41 PM                                                                                                                    
                                                                                                                                
DR.  HEANEY  addressed  slide  25,  "Rickets  Rises  Again,"  and                                                               
analyzed  the cause  to  be decreased  sun  exposure for  babies,                                                               
maternal vitamin  D deficiency, and failure  to supplement infant                                                               
feedings  with 400  IU/daily  of  vitamin D.    He expressed  his                                                               
concern that  Canadian babies received a  vitamin supplement, but                                                               
that US babies did not.                                                                                                         
                                                                                                                                
3:30:06 PM                                                                                                                    
                                                                                                                                
DR. HEANEY,  citing slide 26, "Craniotabes  in "Normal" Infants,"                                                               
stated  that  a Japanese  study  indicated  that 22  percent  had                                                               
craniotabes, with a median vitamin D of less than 10 ng/mL.                                                                     
                                                                                                                                
3:30:52 PM                                                                                                                    
                                                                                                                                
DR. HEANEY shared  slide 27 and slide 28, which  depicted a young                                                               
girl pre  and post  treatment for rickets,  and he  questioned if                                                               
there would  be any subtle  long term consequences to  early life                                                               
vitamin D deficiency.                                                                                                           
                                                                                                                                
3:31:28 PM                                                                                                                    
                                                                                                                                
DR. HEANEY evaluated slide 29,  slide 30, and slide 31, "Juvenile                                                               
Diabetes in Finland,"  a graph of boys and girls  ages 1-14 years                                                               
for more  than 30 years, from  the mid 1960's to  the mid 1990's.                                                               
The horizontal axis was chronological  time and the vertical axis                                                               
was  incidences of  diabetes per  year.   He shared  that Finland                                                               
kept   excellent  medical   records   and  was   able  to   track                                                               
populations.  He  pointed to the line for ages  1-4, which showed                                                               
an increase from  10 per 100,000 incidences each year  of the mid                                                               
1960's, to almost 35 incidences each  year of the mid 1990's.  He                                                               
noted  that the  lines  for  ages 5-9  and  for  ages 10-14  each                                                               
reflected this  same trend.  He  opined that this would  "lead to                                                               
long term  downstream consequences."   He stated that HHSS  had a                                                               
responsibility to make  recommendations, even if it  did not make                                                               
decisions about  diagnosis or treatment.   Directing attention to                                                               
slide 30,  he noted that,  in 1960, the  intake of vitamin  D for                                                               
infants  was 4500  IU  per  day.   He  reported  that the  common                                                               
practice in  Eastern Europe  and Scandinavia  was for  infants to                                                               
receive  600,000 IU  three times  each year.   Slide  30 depicted                                                               
decreases  of the  recommended dosage  of vitamin  D in  1964, in                                                               
1975, and  again in  1993, to 400  IU per day  which was  now the                                                               
same recommended dosage  as the US.  He stated  that an after the                                                               
fact comparative  analysis of diabetes and  recommended dosage of                                                               
vitamin D reflected an increase of juvenile diabetes.                                                                           
                                                                                                                                
3:34:31 PM                                                                                                                    
                                                                                                                                
DR. HEANEY turned to slide 32,  slide 33, and slide 34, "Neonatal                                                               
Vit  D  &  Diabetes,"  which   charted  10,336  northern  Finnish                                                               
children in relation to the  recommended vitamin D dosage of 2000                                                               
IU  per day  for the  first  year of  life.   He categorized  the                                                               
children into four groups:   those who got the recommended amount                                                               
regularly; those  who got it  sometimes; those who got  it never;                                                               
and those who got little or no  vitamin D at all and were thought                                                               
to  have rickets.    The  study tracked  these  children for  the                                                               
prevalence  of Type  1 diabetes  at  age 31,  and calculated  the                                                               
relative risk  of developing diabetes under  these circumstances.                                                               
He pointed  out that  the children  who received  the 2000  IU of                                                               
vitamin D  daily for  the first  year of life  had an  88 percent                                                               
lower  risk of  having diabetes  at  age 31;  those children  who                                                               
received the dosage  sometimes had an 80 percent  lower risk; and                                                               
those  children  who did  not  receive  any  vitamin D  and  were                                                               
thought  to  have  rickets  had  three times  as  many  cases  of                                                               
diabetes  as those  who never  got vitamin  D, but  did not  have                                                               
rickets.   He stated that  the "burden of chronic  diseases, most                                                               
of which  are multi-factorial,  is made  by inadequate  vitamin D                                                               
status."  He stressed that vitamin D impaired the diseases.                                                                     
                                                                                                                                
3:37:26 PM                                                                                                                    
                                                                                                                                
DR.  HEANEY,  sharing  slide 35,  "What  are  the  Consequences?"                                                               
stated that "we  won't really know the true size  of that chronic                                                               
disease burden  until we  eradicate vitamin  D deficiency  in the                                                               
population."   He  stated that  when everyone  reached a  certain                                                               
vitamin D level, chronic diseases levels would drop.                                                                            
                                                                                                                                
3:38:04 PM                                                                                                                    
                                                                                                                                
DR.   HEANEY  directed   attention  to   slide  36,   "Vit  D   &                                                               
Cardiovascular Disease," explaining the  parameters of the study:                                                               
1739 Framingham offspring members; average  age was 59 years; and                                                               
the  follow  up was  for  5.4  years.    During this  study,  120                                                               
individuals  had  a  major  cardiovascular  event,  either  heart                                                               
failure, mild  cardio infarction, or  cardiac death.   This graph                                                               
depicted the  hazard ratio (HR)  on the vertical axis,  which was                                                               
calculated against the vitamin D  usage, above or below 15 ng/mL,                                                               
on the  horizontal axis.  He  emphasized that 15 ng/mL  was still                                                               
insufficient  for  a  healthy  range.     He  stated  that  those                                                               
individuals  with a  vitamin  D value  below 15  ng/mL  had a  53                                                               
percent increase in cardiovascular  risk, while those individuals                                                               
below 10 ng/mL had an 80 percent risk increase.                                                                                 
                                                                                                                                
3:39:26 PM                                                                                                                    
                                                                                                                                
DR. HEANEY  moved to  the next  slide, "Calcium,  Vit D,  & Blood                                                               
Pressure."   This  reflected that  148 women  in Germany,  age 74                                                               
years with  a vitamin D level  below 50 nmol/L, were  tested in a                                                               
double blind,  randomized placebo control  trial.  The  bar graph                                                               
charted  systolic  blood  pressure  on  the  vertical  axis  with                                                               
calcium only and  calcium plus vitamin D on  the horizontal axis.                                                               
The question posed was whether  calcium, with vitamin D, was more                                                               
effective  than  simple  calcium  for  lowering  blood  pressure.                                                               
After  eight  weeks  of  treatment,  the  findings  indicated  an                                                               
additional 7  point drop in  blood pressure for the  calcium with                                                               
vitamin D group.                                                                                                                
                                                                                                                                
3:41:16 PM                                                                                                                    
                                                                                                                                
DR.  HEANEY  addressed  slide 38,  "Breast  Cancer  Risk,"  which                                                               
depicted  the graph  of a  study for  the odds  ratio for  cancer                                                               
inversely associated with vitamin D  status.  He noted that there                                                               
were 1394  cases and 1365  controls, and the study  reflected the                                                               
vitamin D range from less than  30 nmol/L to more than 75 nmol/L.                                                               
He reminded  that more than  100 nmol/L  was a healthy  level, so                                                               
this study reflected  the less healthy aspect.  The  less than 30                                                               
nmol/L group  was the baseline for  the study.  He  reported that                                                               
the  risk for  having breast  cancer decreased  as the  vitamin D                                                               
status improved.   The group with  a vitamin D reading  of higher                                                               
than  75 nmol/L  had  a  69 percent  decrease  in  risk from  the                                                               
baseline group.                                                                                                                 
                                                                                                                                
3:42:16 PM                                                                                                                    
                                                                                                                                
DR. HEANEY described  slide 39, "Diabetes & 25(OH)D,"  a study of                                                               
the  blood sugar,  predicted by  body mass  index (BMI),  of 6228                                                               
adults.   The study measured vitamin  D in each person,  used the                                                               
bottom quartile  of patients as  the baseline, and  then measured                                                               
the  three other  quartiles  for relative  risk  to the  baseline                                                               
group.   It was noted that  the highest vitamin D  quartile had a                                                               
75 percent lower risk for diabetes.                                                                                             
                                                                                                                                
3:43:34 PM                                                                                                                    
                                                                                                                                
DR. HEANEY  presented slide  40, "Vitamin  D &  Influenza," which                                                               
studied  208  African-American  post   menopausal  women  with  a                                                               
baseline vitamin  D of 18.5  ng/mL, well below the  healthy level                                                               
of  40 ng/mL,  for three  years.   The study  resulted in  a two-                                                               
thirds reduction in influenza by  the group receiving the vitamin                                                               
D  supplement over  the group  given the  placebo.   He explained                                                               
that  preventive outcomes  were assessed  by something  which did                                                               
not happen, and  this was most easy to recognize  in a randomized                                                               
controlled trial where each individual had to be tracked.                                                                       
                                                                                                                                
DR.  HEANEY  indicated  slide  41  and slide  42,  "Vitamin  D  &                                                               
Caesareans," which  measured the vitamin  D of 253  women shortly                                                               
after birth.   He  acknowledged that the  risk for  Caesarean was                                                               
four times higher if there was a lower vitamin D.                                                                               
                                                                                                                                
3:46:43 PM                                                                                                                    
                                                                                                                                
DR. HEANEY  moved on to slide  43, slide 44, slide  45, and slide                                                               
46, "Vit D  & Pregnancy Outcomes."  He explained  that this study                                                               
was for  690 pregnant women, and  they were dosed with  vitamin D                                                               
amounting to 400,  2000, or 4000 IU each day,  from week 12 until                                                               
delivery.   The study reflected the  time frame for vitamin  D to                                                               
be absorbed into  the blood, and the relative  risk for pregnancy                                                               
outcomes.   Comparing the 400 IU  group to the 4000  IU group, it                                                               
was shown  that the risk  of untoward  outcomes was half  for the                                                               
4000  IU group.    He  noted that,  beyond  the  human cost,  the                                                               
financial cost difference was substantial.                                                                                      
                                                                                                                                
3:49:10 PM                                                                                                                    
                                                                                                                                
DR.  HEANEY introduced  slide  47, "Vit  D  & Nursing  Outcomes,"                                                               
which compared the  vitamin D level in a mother's  milk with that                                                               
in  the mother's  blood.   The  results showed  that adding  more                                                               
vitamin D to a woman's blood, meant more vitamin D in her milk.                                                                 
                                                                                                                                
3:50:27 PM                                                                                                                    
                                                                                                                                
DR. HEANEY  assessing slide  48, "Colorectal  Cancer," summarized                                                               
that the higher  the vitamin D level, the less  likely the cancer                                                               
would develop, by almost a 50 percent reduction.                                                                                
                                                                                                                                
3:51:12 PM                                                                                                                    
                                                                                                                                
DR.  HEANEY  described  slide  49  and slide  50,  "Vitamin  D  &                                                               
Cancer," which examined a four  year study of 1179 healthy women,                                                               
between  59 and  74 years  of age.   There  were three  treatment                                                               
groups:   the  placebo control  group, the  group which  received                                                               
calcium only,  and the group  which received calcium and  1100 IU                                                               
per day of vitamin  D.  The results were a  77 percent lower risk                                                               
for cancer with the calcium and  vitamin D, than with the placebo                                                               
control group.  He noted slide  51, "Cancers by Treatment (yrs. 2                                                               
- 4),"  which compared  breast, colon,  lung, lymphoma  and other                                                               
cancers, and he  compared the reductions for each  type of cancer                                                               
by the calcium with vitamin D group.                                                                                            
                                                                                                                                
3:53:30 PM                                                                                                                    
                                                                                                                                
DR. HEANEY reviewed slide 52,  "Status of the Evidence," and said                                                               
"there  are  now more  than  40  randomized trials  evaluating  a                                                               
causal connection  between [vitamin D] levels  and various health                                                               
outcomes."   He listed some of  these trials to include:   falls,                                                               
hypertension, cancer, respiratory  infection, pregnancy outcomes,                                                               
and  diabetes.    He  ascertained   that  there  were  a  lot  of                                                               
randomized trials  which offered a  "huge body of  evidence there                                                               
that, for some reason, the regulatory bodies seem to ignore."                                                                   
                                                                                                                                
DR. HEANEY  asked the question  on slide 53:   "How can  a single                                                               
nutrient  have   such  diverse  effects  in   so  many  different                                                               
tissues?"  He directed attention  to slide 56, "Cell Models," and                                                               
explained that  the old cell models  had stated there was  DNA in                                                               
the nucleus,  which were  the full  plans used  for cloning.   He                                                               
reported that  new models stated that  DNA functioned "constantly                                                               
in the synthesis of needed  cellular apparatus, without the cells                                                               
multiplying at all."                                                                                                            
                                                                                                                                
3:55:52 PM                                                                                                                    
                                                                                                                                
DR. HEANEY, sharing  slide 57, "Cell Models," stated  that it was                                                               
previously  thought  that  each  cell  type  contained  different                                                               
cytoplasmic  apparatus;  however,  new  thought  focused  on  the                                                               
differentiation to mean  that only certain genes  can be accessed                                                               
in  each  cell.   For  example,  muscle  cells access  the  genes                                                               
necessary for muscle  function, and white blood  cells access the                                                               
genes that facilitate white blood function.                                                                                     
                                                                                                                                
3:56:40 PM                                                                                                                    
                                                                                                                                
DR. HEANEY  explained slide 57,  slide 58,  and slide 59,  "How a                                                               
Cell Responds."  He stated that  as a signal impacted a cell, the                                                               
cell response was to search "the plans  for what I need in my DNA                                                               
library."   The cell  nucleus "opens  up the  plans and  the cell                                                               
immediately  synthesizes  the  needed cellular  equipment."    He                                                               
confirmed that  the active form  of vitamin  D was the  key "that                                                               
unlocks the  DNA library; without it  the cells can't get  in and                                                               
find  the plans  that they  need in  order to  respond to  normal                                                               
signals."   He clarified that  this vitamin D was  synthesized in                                                               
the cell itself, not circulated in the blood.                                                                                   
                                                                                                                                
3:58:26 PM                                                                                                                    
                                                                                                                                
DR. HEANEY read slide 61, "things  go better with Vitamin D," and                                                               
emphasized that "everything  works better if you  get the vitamin                                                               
D  status up  to a  normal  level."   He confirmed  that, in  the                                                               
absence of Vitamin  D, the body could not deal  with the problems                                                               
as  well,  as  the  body  needed the  vitamin  D  to  access  the                                                               
information  stored  in  the  cells.    He  indicated  slide  62,                                                               
"Perspective,"  and   declared:    "Vitamin  D   is  an  integral                                                               
component  of the  mechanism whereby  cells respond  to signals."                                                               
He read:  "Adequate vitamin  D status enables optimal response to                                                               
a broad variety of signals  and expression of deficiency [status]                                                               
will vary  from person to  person depending  upon tissue-specific                                                               
sensitivity."                                                                                                                   
                                                                                                                                
3:59:32 PM                                                                                                                    
                                                                                                                                
DR.  HEANEY  supplied  slide  63,  "Vitamin  D  -  Sources,"  and                                                               
emphasized the  need for at  least 4000 IU  per day.   He pointed                                                               
out that,  in Alaska,  as the  sun was not  a viable  source, the                                                               
focus needed  to be on food  and supplements.  Pointing  to slide                                                               
64, "Vitamin  D Intake &  Toxicity," he offered  reassurance that                                                               
there was  no vitamin D  toxicity when  the dosage was  less than                                                               
30,000 IU per day.                                                                                                              
                                                                                                                                
4:01:47 PM                                                                                                                    
                                                                                                                                
DR.    HEANEY   presented    slide    62,   "Fortification    vs.                                                               
Supplementation," and emphasized that both  will work, in theory.                                                               
He explained  that supplementation required  voluntary compliance                                                               
and  commitment,  a  result  of  education  and  promotion.    He                                                               
directed   attention  to   proposed   HJR  5   and  stated   that                                                               
fortification  offered  the best  long  term  effectiveness.   He                                                               
suggested the addition  of at least 1000 IU per  day to the diets                                                               
of  most Alaskans,  and offered  as  an example  the addition  of                                                               
vitamin D to  all wheat flour products.  He  summarized slide 63,                                                               
"The Prevention Paradox," "A preventive  measure that brings much                                                               
benefit to the  population... usually offers very  little to each                                                               
participating  individual, that  is  the people  don't feel  that                                                               
they've gotten  one."  He  offered his  belief that a  portion of                                                               
the population and some physicians  would become convinced of the                                                               
value, but that  the majority of the population  would not notice                                                               
any advantage.                                                                                                                  
                                                                                                                                
4:03:53 PM                                                                                                                    
                                                                                                                                
DR. HEANEY closed  his PowerPoint presentation with  slide 64 and                                                               
slide  65,  "The Naaman  Syndrome,"  and  recounted the  biblical                                                               
story of  Naaman, the  Syrian general,  in 2  Kings 5:12-14.   He                                                               
concluded  that  the problem  was  that  "if something  is  easy,                                                               
inexpensive, and  safe, it can't be  any good" or "if  this is so                                                               
great, why isn't everybody doing it already?"                                                                                   
                                                                                                                                
4:06:52 PM                                                                                                                    
                                                                                                                                
CAROLE  A  BAGGERLY,   Director,  GrassrootsHealth,  presented  a                                                               
PowerPoint, "Vitamin D Prevents  What's Next?" and explained that                                                               
GrassrootsHealth,   a   non-profit   consortium  of   Vitamin   D                                                               
researchers, was formed in 2007.                                                                                                
                                                                                                                                
MS. BAGGERLY directed attention to slide  2, slide 3 and slide 4,                                                               
"Alaska Statistics."   She noted that, in Alaska,  there were 372                                                               
breast  cancer  diagnoses  each  year,   with  a  total  cost  of                                                               
$27,911,341.  She stated that a  reduction of 20 percent with use                                                               
of  vitamin  D,  although  one researcher  had  projected  an  80                                                               
percent reduction  with vitamin D  use, would result in  74 fewer                                                               
diagnoses with a savings of $5,582, 268.                                                                                        
                                                                                                                                
4:08:44 PM                                                                                                                    
                                                                                                                                
MS. BAGGERLY  reported that at  least 10  percent of the  over 65                                                               
population would be injured by a  fall, at a cost of $10,555 each                                                               
fall, for a projected cost  to Alaskans of $58,052,500 each year.                                                               
She cited  that the use of  vitamin D would increase  healing and                                                               
result in a 20 percent cost reduction, a savings of $11,610,500.                                                                
                                                                                                                                
4:09:43 PM                                                                                                                    
                                                                                                                                
MS. BAGGERLY  detailed that  11 percent of  births would  be pre-                                                               
term births, earlier  than 34 weeks, with a  cost of $64,075,200;                                                               
whereas   a   50   percent  potential   prevention   would   save                                                               
$32,037,600.    She directed  attention  to  slide 5,  "Potential                                                               
Benefit of  3 Conditions,"  and declared  the savings,  just from                                                               
these three  conditions, could total  $49,230,368.   She referred                                                               
to slide  6, "Cost of  supplementation for  626,932 people/year,"                                                               
and declared that  the cost of supplementing each  Alaskan at $36                                                               
each per  year, would be  $22,883,000.  She subtracted  this from                                                               
the  earlier potential  savings of  $49,230,368 and  declared the                                                               
net savings  benefit for  Alaska to be  $26,347,368.   She agreed                                                               
that some of  this savings would need to be  spent on testing and                                                               
education programs, and she suggested  spending some of this on a                                                               
special  program of  supplementation for  pregnant women,  people                                                               
over 65, and  all cancer patients.  She declared  that this would                                                               
result in an immediate impact.                                                                                                  
                                                                                                                                
4:12:01 PM                                                                                                                    
                                                                                                                                
MS.   BAGGERLY  presented   slide  7,   "How  to   prevent  these                                                               
conditions?"  and  announced that  attaining  a  vitamin D  serum                                                               
[blood] level of 40-60 ng/mL would be a solution.                                                                               
                                                                                                                                
MS. BAGGERLY moved on to  slide 8, "Disease Incidences Prevention                                                               
by  Serum 25(OH)D  Level," and  discussed the  various incidences                                                               
that could be prevented by attaining this serum level.                                                                          
                                                                                                                                
4:12:52 PM                                                                                                                    
                                                                                                                                
MS. BAGGERLY  supplied slide  9, "What's in  place to  solve this                                                               
problem?" and  reviewed the  Vitamin D*action  Community Project.                                                               
She  explained that  3708 people  had volunteered  to get  tested                                                               
every six  months for vitamin D  levels and to fill  out a health                                                               
questionnaire.  She referred to  slide 11, which depicted that 47                                                               
percent  of  the  people  were vitamin  D  deficient  when  first                                                               
tested.   She  pointed  to the  results of  the  second test  six                                                               
months later on  slide 12, reporting that only 24  percent of the                                                               
group was now  deficient, as people were paying  attention to the                                                               
vitamin D  intake.   She directed attention  to the  test results                                                               
after one  year, slide 13, which  showed that only 10  percent of                                                               
the group  was now deficient.   She noted that the  costs for the                                                               
supplement, the monitoring, and the tests were trivial.                                                                         
                                                                                                                                
4:14:11 PM                                                                                                                    
                                                                                                                                
MS. BAGGERLY shared  slide 14, "D*action Project:  Serum Level vs                                                               
Intake"  and announced  that  the results  from  this study  were                                                               
about to be  published.  She pointed to the  necessity of testing                                                               
serum level, as supplements affected  each individual's vitamin D                                                               
serum level differently.                                                                                                        
                                                                                                                                
4:16:27 PM                                                                                                                    
                                                                                                                                
MS.  BAGGERLY stated  that  slide 15,  "Key  Results of  D*action                                                               
Project,"  reflected that  the public  was ready  for this.   She                                                               
said  that with  5000 IU  per day,  more than  88 percent  of the                                                               
group had  a serum level  greater than  40 ng/mL.   She described                                                               
slide  16,  "Major  Goals  with   D*action  in  5  Years  in  Any                                                               
Community,"  and  announced  that  the goal  was  to  reduce  the                                                               
incidences of  breast cancer, colon cancer,  and pre-term births,                                                               
among others, by  25 percent, educate the public  and health care                                                               
personnel,  and  develop  public  health  policy  actions.    She                                                               
pointed  to slide  17 and  slide 18,  and shared  that education,                                                               
vitamin D testing, feedback, and  community action plans were the                                                               
means to attain this goal.                                                                                                      
                                                                                                                                
4:18:37 PM                                                                                                                    
                                                                                                                                
MS.  BAGGERLY read  a quote  from slide  19, "Action  springs not                                                               
from thought but from a readiness for responsibility."                                                                          
                                                                                                                                
4:19:38 PM                                                                                                                    
                                                                                                                                
SENATOR CATHY GEISSEL, Alaska State  Legislature, shared that she                                                               
was also  a nurse practitioner and  had been advising the  use of                                                               
Vitamin D as a supplement for nine years.                                                                                       
                                                                                                                                
4:20:20 PM                                                                                                                    
                                                                                                                                
REPRESENTATIVE  DICK asked:    was Vitamin  D  cumulative in  the                                                               
body, was there  a shelf life for vitamin D  supplements, and was                                                               
there any negative effect to freezing vitamin D supplements.                                                                    
                                                                                                                                
4:20:53 PM                                                                                                                    
                                                                                                                                
DR.  HEANEY,  in  response to  Representative  Dick,  said  that,                                                               
although it  was cumulative, 4-5000  IU could be taken  daily and                                                               
would not accumulate to toxic levels  in the fat.  He shared that                                                               
vitamin D deteriorated about 1  percent each month, but that many                                                               
manufacturers overloaded  the capsules by  about 10 percent.   He                                                               
said that  there was  not any harm  to freezing  the supplements,                                                               
but he did not know if this slowed the deterioration.                                                                           
                                                                                                                                
4:22:21 PM                                                                                                                    
                                                                                                                                
DR. HEANEY,  in response to  Chair Keller, said that  studies all                                                               
showed  there  was a  difference  for  individual response.    He                                                               
relayed that  an important question  was whether  poor responders                                                               
were being under treated or  exuberant responders were being over                                                               
treated.   The only known factor  was that bigger people  did not                                                               
get as big a response.                                                                                                          
                                                                                                                                
4:23:53 PM                                                                                                                    
                                                                                                                                
CHAIR KELLER asked if it was  common knowledge that vitamin D was                                                               
the key to unlock the DNA.                                                                                                      
                                                                                                                                
DR. HEANEY  replied that  these cell  biology studies  were about                                                               
three years old.   He pointed out  that vitamin D as a  key for a                                                               
cell was  older knowledge,  but only recently  had this  key been                                                               
linked to the entire body.                                                                                                      
                                                                                                                                
4:26:26 PM                                                                                                                    
                                                                                                                                
DR. HEANEY  opined that the  first year  of life was  crucial for                                                               
the  immune  system to  differentiate  self  from non-self.    He                                                               
confirmed that both  Type 1 diabetes and  multiple sclerosis were                                                               
auto immune diseases.                                                                                                           
                                                                                                                                
4:28:42 PM                                                                                                                    
                                                                                                                                
MS.  BAGGERLY  referred to  a  study  in  Canada which  showed  a                                                               
significant  decrease  in the  recurrence  of  breast cancer  for                                                               
people with higher levels of vitamin D.                                                                                         
                                                                                                                                
4:29:10 PM                                                                                                                    
                                                                                                                                
REPRESENTATIVE       SEATON      directed       attention      to                                                               
www.grassrootshealth.org   and   said  that   the   presentations                                                               
available   on  the   website  detailed   the  cellular   biology                                                               
mechanism.   He noted  that Alaska  Natives eating  a traditional                                                               
diet were the  only group to have an adequate  dietary vitamin D.                                                               
He  pointed out  that even  during  times of  peak sun,  Alaskans                                                               
remained covered up.                                                                                                            
                                                                                                                                
4:32:37 PM                                                                                                                    
                                                                                                                                
DR. HEANEY,  in response to  Representative Dick,  explained that                                                               
the  vitamin  D3  was  cholecalciferol,   while  vitamin  D2  was                                                               
ergocalciferol.    He  pointed  out  that  ergocalciferol  was  a                                                               
synthetic  product, while  cholecalciferol  was  produced by  the                                                               
skin.                                                                                                                           
                                                                                                                                
REPRESENTATIVE DICK asked what part  of the animal might have the                                                               
most Vitamin D 3.                                                                                                               
                                                                                                                                
DR. HEANEY  offered his  belief that it  was not  concentrated in                                                               
the  liver  or  the  kidneys,  but primarily  in  the  fat.    He                                                               
suggested that  there was not  much research on meat  sources for                                                               
vitamin  D.    He  noted that  the  molecules  closely  resembled                                                               
cholesterol molecules.                                                                                                          
                                                                                                                                
REPRESENTATIVE SEATON  pointed out  the low  cost for  Vitamin D3                                                               
supplements.                                                                                                                    
                                                                                                                                
4:39:18 PM                                                                                                                    
                                                                                                                                
DR. HEANEY  emphasized that the  immune system needed  Vitamin D,                                                               
and that it enabled the body's repair and defense mechanism.                                                                    
                                                                                                                                
4:39:47 PM                                                                                                                    
                                                                                                                                
SENATOR  GEISSEL reflected  on cod  liver oil  and salmon  oil as                                                               
being high in vitamin D.   She reported that [wild] Alaska salmon                                                               
was low in toxins, but high in Vitamin D.                                                                                       
                                                                                                                                
DR. HEANEY,  in response to  Chair Keller, said that  farm raised                                                               
salmon had 90 percent less Vitamin D than wild salmon.                                                                          
                                                                                                                                
4:41:00 PM                                                                                                                    
                                                                                                                                
MS.  BAGGERLY observed  that it  would  be necessary  to eat  ten                                                               
servings daily of salmon to receive adequate vitamin D.                                                                         
                                                                                                                                
4:43:19 PM                                                                                                                    
                                                                                                                                
ADJOURNMENT                                                                                                                   
                                                                                                                                
There being no  further business before the  committee, the House                                                               
Health  and  Social  Services   Standing  Committee  meeting  was                                                               
adjourned at 4:43 p.m.                                                                                                          

Document Name Date/Time Subjects
Alaska 021711.ppt HHSS 2/17/2011 3:00:00 PM
Medline Plus 1 Vit D.pdf HHSS 2/17/2011 3:00:00 PM
Medline Plus 2 Vit D.pdf HHSS 2/17/2011 3:00:00 PM
VitD for Alaska Heaney revised.ppt HHSS 2/17/2011 3:00:00 PM